Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.

Brock Purdy could return to practice in a limited capacity ahead of Week 3 after a toe injury, raising optimism for a possible Week 3 return or emergency third QB setup vs Arizona. Eight 49ers missed practice, including Kyle Juszczyk and Siran Neal with concussions and key vets like Trent Williams, Nick Bosa, and Christian McCaffrey on rest days or limited designations. The latest timeline hints Purdy could be back sooner than feared, with a two-week recovery being plausible.

Fantasy angle: Purdy’s return would reshape San Francisco’s aerial ceiling, while McCaffrey’s workload is a key watch given the injury designations. Jennings and Williams are trending to play, but neck-and-neck with health; Juszczyk/Neal concussion protocols add depth risk. Week 3 game plan against Arizona looms large for SF’s offense and fantasy upside.

Brock Purdy's turf toe has him limited at practice with a real chance to play Week 3 against Arizona. Shanahan will gauge reps to reintegrate him, a step SF needs after a banged-up 2024 and George Kittle being on IR. Mac Jones filled in Week 2 and SF won, but Purdy's health remains the keystone for fantasy value and divisional plans.

If Purdy suits up, expect SF to blend quick passes with a steady run game, keeping targets spread but leaning on McCaffrey and the receiving corps. If he sits, Jones or a scaled-back script could shift the offense, lifting or lowering fantasy upside across the lineup as SF guards Purdy's timetable.

The Week 3 matchup vs Arizona becomes a litmus test for Purdy's timetable and the offense's staying power as SF navigates a tough division; the team’s depth and return timeline will shape weekly fantasy projections far beyond this week.

San Francisco 49ers prep for Week 3 against the Arizona Cardinals as Brock Purdy’s toe injury looms. Purdy is progressing and could serve as the emergency backup or even the No. 2 quarterback if his week goes well, per coach Kyle Shanahan. Several teammates are on the injury report, including Juszczyk, Burford, Neal, Williams, McCaffrey and Bosa, with Purdy himself listed as limited. The plan hinges on how the toe responds through the week.

Mac Jones’ performance is cited only for context, not as a rush to replace Purdy. Arizona presents a test, but the 49ers must balance rest and availability for a Week 3 showdown that could shape early-season depth charts and fantasy value across multiple SF players.